Sleep deprivation is a condition that occurs when you don’t get enough sleep, or enough good quality sleep. While it affects mood, memory, and energy, it can also contribute to inflammation.
Research has found that sleep deprivation is associated with markers of inflammation, such as increases in inflammatory molecules — including cytokines, interleukin-6, C-reactive protein (a marker of inflammation that’s elevated in people at risk for heart disease and diabetes), and others.
Inflammation is the body’s natural response to disease and injury; it is usually a temporary response and serves as an effective defense mechanism. But when inflammation doesn’t let up, it can contribute to the development of heart disease, diabetes, stroke, cancer, and Alzheimer’s disease.
In addition, a sleep shortfall interferes with the normal function of the brain’s housecleaning system, termed the glymphatic system (not to be confused with the lymphatic system in the rest of the body). In the deepest sleep phases, cerebrospinal fluid rushes through the brain, sweeping away beta-amyloid protein linked to brain cell damage.
Without a good night’s sleep, this housecleaning process is less thorough, allowing the protein to accumulate — and inflammation to develop. Then, a vicious cycle sets in. Beta-amyloid buildup in the brain’s frontal lobe starts to impair deeper, non-REM slow-wave sleep. This damage makes it harder both to sleep and to retain and consolidate memories.
Just one night of lost sleep can keep beta-amyloid levels higher than usual. The problem is not so much a single night’s poor sleep, which you can compensate for, but a cumulative pattern of sleep loss, leading to decreases in the structural integrity, size, and function of brain regionslike the thalamus and hippocampus, which are especially vulnerable to damage during the early stages of Alzheimer’s disease.
It is important to highlight that both too much and too little sleep appears to be associated with inflammation, a process that contributes to depression as well as many medical illnesses.
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